Umbilical & Placental Cell News Volume 15.18 | May 18 2023

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    2023-05-18 | UPCN 15.18


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    Vol. 15.18 – 18 May, 2023
    TOP STORY

    Clinical-Grade Human Umbilical Cord-Derived Mesenchymal Stem Cells Improved Skeletal Muscle Dysfunction in Age-Associated Sarcopenia Mice

    Clinical-grade human umbilical cord-derived MSCs were administrated to two classic mouse models, and their effects on skeletal muscle mass and function were investigated by behavioral tests, immunostaining, and western blotting.
    [Cell Death & Disease]

    Full ArticleGraphical Abstract
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    PUBLICATIONSRanked by the impact factor of the journal

    Self-Assembled Human Placental Model from Trophoblast Stem Cells in a Dynamic Organ-on-a-Chip System

    The authors described a biomimetic placental barrier model from human trophoblast stem cells (hTSCs) in a perfused organ chip system. The placental barrier was constructed by co-culture of hTSCs and endothelial cells on the opposite sides of a collagen-coated membrane on chip.
    [Cell Proliferation]

    Full Article

    Cytokine-Stimulated Human Amniotic Epithelial Cells Alleviate DSS-Induced Colitis in Mice through Anti-Inflammation and Regulating Th17/Treg Balance

    Scientists aimed to optimize and maximize the therapeutic potential of human amniotic epithelial cells by pre-treating them with tumor necrosis factor-α and interferon-γ for ulcerative colitis treatment.
    [International Immunopharmacology]

    Abstract

    Human Wharton’s Jelly Mesenchymal Stem Cells Derived-Exosomes Enriched by miR-124 Promote an Anti-Fibrotic Response in an Experimental Model of Liver Fibrosis

    The authors investigated whether delivery of miR-124 through human Wharton’s jelly MSCs derived exosomes could improve liver fibrosis.
    [International Immunopharmacology]

    Abstract

    Outcomes of Graft Failure after Umbilical Cord Blood Transplantation in Acute Leukemia: A Study from Eurocord and the Acute Leukemia Working Party of the EBMT

    Investigators assessed the outcomes of patients who experienced graft failure after umbilical cord blood transplantation.
    [Bone Marrow Transplantation]

    Abstract

    Purification of Primary Human Placental Leukocytes to Study Maternal-Fetal Interactions

    Researchers presented detailed methods to purify, culture, and functionally analyze human placental dNK, dTreg, dTem, and dMɸ from decidua parietalis.
    [Star Protocols]

    Full ArticleGraphical Abstract
    Try proven workflows for your hPSC culture. Click to request your offer now.
    REVIEWS

    The Placenta: Epigenetic Insights into Trophoblast Developmental Models of a Generation-Bridging Organ with Long-Lasting Impact on Lifelong Health

    Scientists provide an overview of placental development and highlight the instructional role of the epigenome in dictating cell fate decisions specifically in the placental trophoblast cell lineage.
    [Physiological Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves Cord-Blood Therapy

    The US FDA has approved an umbilical cord blood-based therapy for blood-cancer patients requiring a stem cell transplant.
    [Nature Biotechnology]

    Abstract
    FEATURED EVENT

    Annual Regenerative Medicine Essentials Summer Course and RMF Stem Cell Summit

    June 5 – 8, 2023
    Winston-Salem, North Carolina, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Clinical Chemistry and Molecular Diagnostics

    University of Leipzig – Leipzig, Germany

    Production Manager – Equine MSCs

    Boehringer Ingelheim – Ingelheim, Germany

    Postdoctoral Positions – Reproductive Immunology and Pregnancy Biology

    University of California San Francisco – San Francisco, California, United States

    Senior Associate – Cell and Organoid Biorepository

    Roche Institute of Translational Bioengineering – Zurich, Switzerland

    Research Associate – Cell Therapy Processes

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    > See All Jobs

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