Umbilical & Placental Cell News Volume 15.19 | May 25 2023

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    2023-05-25 | UPCN 15.19


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    Vol. 15.19 – 25 May, 2023
    TOP STORY

    Modeling Human Ectopic Pregnancies with Trophoblast and Vascular Organoids

    Scientists employed cell culture and organoid models to investigate the crosstalk between human trophoblast development and intravillous vascularization in the ruptured ectopic pregnancy condition.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    PUBLICATIONSRanked by the impact factor of the journal

    Granulocyte Transfusion during Cord Blood Transplant for Relapsed, Refractory AML Is Associated with Massive CD8+ T Cell Expansion, Significant Cytokine Release Syndrome and Induction of Disease Remission

    Researchers reported the safety and tolerability of cord blood transplant recipients receiving granulocyte transfusions, T cell expansion data, immunophenotype, cytokine profiles and clinical response in children with post-transplant relapsed acute leukemia.
    [British Journal Of Haematology]

    Full Article

    A Murine Calvarial Defect Model for the Investigation of the Osteogenic Potential of Newborn Umbilical Cord Mesenchymal Stem Cells in Bone Regeneration

    Investigators evaluated the efficacy of using tissue-derived human umbilical cord MSC and their osteogenic capabilities in a murine model to improve alveolar cleft repair.
    [Plastic And Reconstructive Surgery]

    Abstract

    Protecting Human Amnion and Chorion Matrices (HACM) during Processing: Performance Enhancement in a Diabetic Mouse Model and Human Co-Culture System

    Treatment of diabetic full thickness excisional wounds with HACM processed with a polyampholyte preservative accentuated the proliferative phase of wound healing that decreased the time necessary to heal wounds.
    [Wound Repair And Regeneration]

    Abstract

    Human Wharton’s Jelly Mesenchymal Stem Cell Secretome Modifies the Processes of Neuroprotection and Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium at Transcriptional Level

    Retinal pigment epithelium cells from passages 5–7 were treated with Wharton’s Jelly MSC secretome for 24 hours at 37◦C and subsequently subjected to RNA extraction and cDNA synthesis. The gene expression level was evaluated using real-time PCR in the treated versus control cells.
    [Molecular Biology Reports]

    Abstract

    HGF-Modified Human Umbilical Cord Mesenchymal Stem Cells Rescue Impaired Ovarian Reserve Function in Chemotherapy-Induced POI Rats by Improving Angiogenesis While Decreasing Apoptosis and Fibrosis in the Ovary

    To improve the effectiveness of naïve human umbilical cord MSC (HUCMSC) treatments on primary ovarian insufficiency, an exogenous gene hepatocyte growth factor (HGF) was used to modify HUCMSC.
    [Tissue and Cell]

    Abstract
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    REVIEWS

    The Role of m6A mRNA Modification in Normal and Malignant Hematopoiesis

    Investigators focus on recent progress in identifying the biological functions of m6A mRNA modification, its regulators, and downstream gene targets during normal and pathological hematopoiesis.
    [Journal of Leukocyte Biology]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves First Topical Gene Therapy for Treatment of Wounds in Patients with Dystrophic Epidermolysis Bullosa

    The US FDA approved Vyjuvek, a herpes simplex virus type 1 vector-based gene therapy, for the treatment of wounds in patients six months of age and older with dystrophic epidermolysis bullosa with mutation(s) in the collagen type VII alpha 1 chain gene.
    [FDA]

    Press Release
    FEATURED EVENT

    International Conference on Malignant Lymphoma

    June 13 – 17, 2023
    Lugano, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Clinical Chemistry and Molecular Diagnostics

    University of Leipzig – Leipzig, Germany

    Postdoctoral Associate – Chromatin Mechanisms

    Virginia Tech – Washington, DC, United States

    PhD Position – Tumor Tissue Engineering

    Universit̩ de Lausanne РLausanne, Switzerland

    Senior Associate – Cell and Organoid Biorepository

    Roche Institute of Translational Bioengineering – Zurich, Switzerland

    Postdoctoral Positions – Reproductive Immunology and Pregnancy Biology

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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