Umbilical & Placental Cell News Volume 15.21 | Jun 8 2023

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    2023-06-08 | UPCN 15.21


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    Vol. 15.21 – 8 June, 2023
    TOP STORY

    Umbilical Cord-Derived Mesenchymal Stromal Cells Preserve Endogenous Insulin Production in Type 1 Diabetes: A Phase I/II Randomised Double-Blind Placebo-Controlled Trial

    The authors investigated the safety and efficacy of treatment with allogeneic Wharton’s jelly-derived MSCs in recent-onset type 1 diabetes.
    [Diabetologia]

    Full ArticlePress Release
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Optogenetic Engineered Umbilical Cord MSC-Derived Exosomes for Remodeling of the Immune Microenvironment in Diabetic Wounds and the Promotion of Tissue Repair

    Researchers discussed the effects and mechanisms of eNOS-rich umbilical cord MSC exosomes modified by genetic engineering and optogenetic techniques on diabetic chronic wound repair.
    [Journal of Nanobiotechnology]

    Full ArticleGraphical Abstract

    MiR-146a-5p Delivered by hucMSC Extracellular Vesicles Modulates the Inflammatory Response to Sulfur Mustard-Induced Acute Lung Injury

    Investigators showed that extracellular vesicles derived from human umbilical cord MSCs could exert therapeutic effects on sulfur mustard-induced acute lung injury, and explained the underlying mechanism of effects.
    [Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Comparison of Biological Characteristics of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells from Extremely Preterm and Term Infants

    Scientists explored the functional differences of human umbilical cord Wharton’s Jelly-derived MSCs between extremely preterm and term infants.
    [Tissue Engineering and Regenerative Medicine]

    Full Article

    Stress Regulation of WFS1 and PERK-P-eIF2α-ATF4 Signaling Pathway in Placental Tissue Cells of Intrahepatic Cholestasis of Pregnancy

    The authors explored the expression level and mutual regulation mechanisms of WFS1 and PERK-mediated unfolded protein response pathway in intrahepatic cholestasis of pregnancy placental tissue cell under stress.
    [Placenta]

    Abstract

    Using Umbilical Cord Blood as a Source of Pediatric Packed Red Blood Cells: Processing and Quality Control

    Researchers adopted two different procedures to obtain umbilical red blood cell (RBC) to compare its quality control parameters to those of fractionated adult RBC, for pediatric purposes.
    [Vox Sanguinis]

    Abstract

    The Transposable Element-Derived Transcript of LIN28B Has a Placental Origin and Is Not Specific to Tumours

    Scientists discovered the co-expression of some transposable elements and oncogenes in human embryonic stem cells and first-trimester and term placental tissues.
    [Molecular Genetics and Genomics]

    Full Article
    Tips to prepare for your next conference or networking event
    REVIEWS

    Stem Cell Sources from Human Biological Waste Material: A Role for the Umbilical Cord and Dental Pulp Stem Cells for Regenerative Medicine

    Investigators present a critical observation of umbilical cord-MSCs and dental pulp-MSCs by reviewing articles from the last two decades along with other stem cell sources from different biological waste materials.
    [Human Cell]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Thousands of Early-Career NIH Researchers Forming Union for First Time

    Thousands of early-career researchers at the US National Institutes of Health (NIH) have kick-started the process of forming a union. They are calling on the agency to raise pay and improve benefits, as well as to bolster its policies and procedures on harassment and excessive workloads.
    [Nature News]

    Press Release
    FEATURED EVENT

    Cell Symposia: Myeloid Cells: From Development to Function and Dysfunction

    June 28 – 30, 2023
    Shanghai, China

    > See All Events

    JOB OPPORTUNITIES

    Research Faculty Position – Placenta Biology & Gynecology

    The Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Research Associate – Bioinformatics & Umbilical Cord Blood

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Research Assistant Professor – Obstetrics and Gynecology

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    PhD Student – Clinical Chemistry and Molecular Diagnostics

    University of Leipzig – Leipzig, Germany

    Postdoctoral Positions – Reproductive Immunology and Pregnancy Biology

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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