Umbilical & Placental Cell News Volume 15.23 | Jun 22 2023

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    2023-06-22 | UPCN 15.23


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.23 – 22 June, 2023
    TOP STORY

    Cord Blood–Derived Vδ2+ and Vδ2 T Cells Acquire Differential Cell State Compositions Upon In Vitro Expansion

    Scientists expanded human cord blood–derived γδ T cells in vitro using an irradiated Epstein-Barr virus–transformed feeder cell–based modified rapid expansion protocol.
    [Science Advances]

    Full Article
    Animal Origin-Free cGMP HSPC Expansion Media
    PUBLICATIONSRanked by the impact factor of the journal

    Acceleration of Burn Wound Healing by Micronized Amniotic Membrane Seeded with Umbilical Cord-Derived Mesenchymal Stem Cells

    In a burn wound model of C57BL/6J mice, topical application of micronized amniotic membrane-MSCs significantly accelerated wound healing compared to MSCs injection alone, and was accompanied by longer survival of MSCs and greater neovascularization in the wound.
    [Materials Today Bio]

    Full ArticleGraphical Abstract

    Functionalized Human Umbilical Cord Mesenchymal Stem Cells and Injectable HA/Gel Hydrogel Synergy in Endometrial Repair and Fertility Recovery

    In an endometrial injury rat model, the treatment with human umbilical cord MSCs-loaded injectable hydrogel significantly enhanced the thickness of the endometrium and increased the abundance of blood vessels and glands in the injured endometrium compared to the control group.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    IFITM1 Inhibits Trophoblast Invasion and Is Induced in Placentas Associated with IFN-Mediated Pregnancy Diseases

    Migration of trophoblast giant cells, the mouse equivalent of human extravillous cytotrophoblasts, was significantly reduced in poly(I:C)-treated mice, and the analysis of CMV-and bacterial-infected human placentas revealed upregulated interferon-induced transmembrane proteins (IFITM1) expression.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Human Amnion-Derived Mesenchymal Stem Cells Attenuate Acute Lung Injury in Two Different Acute Lung Injury Mice Models

    High-dose human amnion-derived MSCs treatment exerted beneficial therapeutic effects on acute lung injury mice models without detectable adverse reactions.
    [Frontiers In Pharmacology]

    Full Article

    hucMSCs Treatment Prevents Pulmonary Fibrosis by Reducing circANKRD42-YAP1-Mediated Mechanical Stiffness

    Target ability of human umbilical cord MSCs (hucMSCs) was examined by labeling with cell membrane dye Dil. Anti-pulmonary fibrosis effect of hucMSCs therapy by reducing mechanical stiffness was evaluated by lung function analysis and MicroCT imaging system and atomic force microscope in vivo and in vitro.
    [Aging-Us]

    Full Article
    Explore this validated protocol for high-efficiency gene editing of Human Pluripotent Stem Cells using the ArciTect™ CRISPR-Cas9 System.
    REVIEWS

    Endometrial and Placental Stem Cells in Successful and Pathological Pregnancies

    The authors review the current knowledge of the different type of stem cells involved in pregnancy initiation and also highlight how their improper functionality leads to pathological pregnancy.
    [Journal Of Assisted Reproduction And Genetics]

    AbstractGraphical Abstract

    Connective Tissue Matrices from Placental Disc for Wound Healing: Mini-Review

    Scientists focus on essential characteristics of placental disc, comparison of four commercially available placental connective matrices obtained from the placental disc, and their supporting studies in the use of wound healing applications.
    [Biotechnology Letters]

    Abstract
    INDUSTRY AND POLICY NEWS

    Transplant Surgeon Sentenced to Prison for Failed Stem Cell Treatments

    Surgeon Paolo Macchiarini, who was once hailed as a pioneer of stem cell medicine, was found guilty of gross assault against three of his patients today and sentenced to 2 years and 6 months in prison by an appeals court in Stockholm.
    [Science Insider]

    Editorial
    FEATURED EVENT

    3rd Tumor Myeloid-Directed Therapies Summit

    July 18 – 20, 2023
    Boston, Massachusetts, United States

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    JOB OPPORTUNITIES

    Clinical Cell Therapy Specialist – GMP Laboratory

    The University of Texas M. D. Anderson Cancer Center – Houston, Texas, United States

    Research Assistant – ESCs & Placenta

    The University of California San Francisco – San Francisco, California, United States

    Research Faculty Position – Placenta Biology & Gynecology

    The Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Research Associate – Bioinformatics & Umbilical Cord Blood

    University of Edinburgh – Edinburgh, Scotland, United Kingdom

    Postdoctoral Positions – Reproductive Immunology & Pregnancy Biology

    University of California San Francisco – San Francisco, California, United States

    > See All Jobs

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