Umbilical & Placental Cell News Volume 15.26 | July 13 2023

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    2023-07-13 | UPCN 15.26


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.26 – 13 July, 2023
    TOP STORY

    Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes

    The essential functional miRNAs within exosomes derived from umbilical cord-derived MSCs were investigated, with the p53 signaling pathway identified as the key factor.
    [ACS Nano]

    AbstractGraphical Abstract
    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Generating Functional Multicellular Organoids from Human Placenta Villi

    Investigators developed a robust, reliable methodology for generating placenta villi organoids from early, late, or diseased pregnancies using air–liquid surface culture.
    [Advanced Science]

    Full Article

    Dual Growth Factor-Modified Microspheres Nesting Human-Derived Umbilical Cord Mesenchymal Stem Cells for Bone Regeneration

    Scientists constructed a micromodule for modular tissue engineering and developed engineered osteon-like microunits by inoculating human-derived umbilical cord MSCs onto nHA/PLGA microspheres with surface modification of dual growth factors.
    [Journal Of Biological Engineering]

    Full Article

    hucMSCs Treatment Ameliorated Pulmonary Fibrosis via Downregulating the circFOXP1–HuR–EZH2/STAT1/FOXK1 Autophagic Axis

    The mechanistic study revealed that the inhibition of human umbilical cord MSCs (hucMSCs) treatment on pulmonary fibrogenesis depended on downregulating circFOXP1, in which hucMSCs (hucMSCs) treatment promoted circFOXP1-mediated autophagy process.
    [Stem Cells]

    Abstract

    Graphical Abstract

    Pretransplant EASIX Score Predicts Non-Relapse and Overall Mortality of Adult Patients Undergoing Single-Unit Unrelated Cord Blood Transplantation

    The authors retrospectively evaluated the impact of The Endothelial Activation and Stress Index (EASIX) score at different time points on post-transplant outcomes in adults following single-unit unrelated cord blood transplantation between 1998 and 2022 at their institute.
    [Transplantation And Cellular Therapy]

    Abstract

    SARS-CoV-2 Niches in Human Placenta Revealed by Spatial Transcriptomics

    By integrating spatial transcriptomes with 273,944 placental single-cell and single-nuclei transcriptomes, investigators generated an atlas composed of at least 22 subpopulations in the maternal decidua, fetal chorionic villi, and chorioamniotic membranes.
    [Med]

    Full ArticleGraphical Abstract
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    REVIEWS

    Body Fluid-Derived Stem Cells — An Untapped Stem Cell Source in Genitourinary Regeneration

    Body fluid-derived stem cells (BFSCs) are more easily accessible through non-invasive or minimally invasive approaches than solid tissue-derived stem cells, and can be isolated without enzymatic tissue digestion. The authors discuss their properties, uses and jthe need for optimization of protocols.
    [Nature Reviews Urology]

    Abstract
    INDUSTRY AND POLICY NEWS

    UK ‘Agrees Deal’ to Rejoin EU’s £81Bn Science Programme after Being Locked Out for Years

    Britain and the EU have reportedly agreed a draft deal that would see the UK rejoin the bloc’s Horizon Europe science programme – amid warnings being outside is “damaging” British science
    [INDEPENDENT]

    Editorial
    FEATURED EVENT

    2023 Hormone-Dependent Cancers Conference GRC

    August 6 – 11, 2023
    Newry, Maine, United States

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Cell Biology and Genetics

    Texas A&M University – College Station, Texas, United States

    Cord Blood Bank – Collector

    Duke University’s Marcus Center for Cellular Cures – Durham, North Carolina, United States

    Senior Applications Programmer – Cord Blood Bank Program

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    Research Assistant – ESCs & Placenta

    The University of California San Francisco – San Francisco, California, United States

    Research Assistant Professor – Obstetrics & Gynecology

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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