 | | Vol. 15.27 – 20 July, 2023 |
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| The authors used a multiomics approach, combining the strengths of spatial proteomics and transcriptomics, to construct a spatiotemporal atlas of the human maternal–fetal interface in the first half of pregnancy.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that prenatal transplantation of human placental cells bioengineered to produce an optimized FVIII protein, resulting in considerable elevation in plasma FVIII levels that persisted for >three years post-treatment.
[Nature Communications] |
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| The human placenta exhibits a unique genomic architecture with an unexpectedly high mutation burden and many uniquely expressed genes. Researchers aimed to identify transcripts that were uniquely absent or depleted in the placenta.
[Cell Reports] |
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| The authors examined whether overexpression of C-X-C chemokine receptor type 7 (CXCR7) in umbilical cord MSCs could improve their homing efficiency, and therefore, improve their effectiveness in fibrosis repair at the site of lung injury caused by acute respiratory distress syndrome.
[Biomedicine & Pharmacotherapy] |
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| Investigators focused on screening the senomorphic properties of Ohwia caudata aqueous extract as an emerging strategy for preventing or treating mitochondrial dysfunction in stem cells.
[Environmental Toxicology] |
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| In comparison to the irradiated group, the irradiated+human umbilical cord blood derived-MSCs group showed restored cell populations and extracellular collagen components of the bone marrow niche with significant increase in hematopoietic stem, progenitor, mature and proliferating cells.
[Annals Of Anatomy-Anatomischer Anzeiger] |
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| The authors first summarize evidence linking ambient temperature or experimentally-induced heat stress with fetal and placental growth outcomes in humans, ruminants, and murine species. They then synthesize the literature on putative underlying biological pathways with a focus on the placenta.
[Molecular And Cellular Endocrinology] |
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| In October 2020, John Carlisle reported a startling estimate of the number of clinical-trial studies in medical journals that are fake or fatally flawed. For more than 150 trials, Carlisle got access to anonymized individual participant data and judged that 44% of the trials contained at least some flawed data.
[Nature] |
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| September 19, 2023
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Duke University’s Marcus Center for Cellular Cures – Durham, North Carolina, United States |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | The University of California San Francisco – San Francisco, California, United States |
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| | The Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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