Umbilical & Placental Cell News Volume 15.28 | Jul 27 2023

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    Laurisa Dohm
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    2023-07-27 | UPCN 15.28


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    Vol. 15.28 – 27 July, 2023
    TOP STORY

    Balance between Maternal Antiviral Response and Placental Transfer of Protection in Gestational SARS-CoV-2 Infection

    By analyzing mother:neonate dyads from second and third trimester SARS-CoV-2 infections, the authors showed that neutralizing antibodies were infrequently detected in cord blood.
    [JCI Insight]

    AbstractGraphical Abstract
    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    GDF-11 Downregulates Placental Human Chorionic Gonadotropin Expression by Activating SMAD2/3 Signaling

    The effects of growth differentiation factor-11 (GDF-11) on CGB expression and human chorionic gonadotropin production, as well as the underlying mechanisms, were explored by a series of in vitro experiments.
    [Cell Communication And Signaling]

    Full Article

    Allogenic Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Motor Function in Prenatal Surgical Repair of Myelomeningocele: An Ovine Model Study

    Scientists compared lambs that received an umbilical cord-MSC patch with a control group of lambs that received an acellular patch.
    [Bjog-An International Journal Of Obstetrics And Gynaecology]

    Abstract

    Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stromal Cells Show Enhanced Anti-Inflammatory Properties via Upregulation of miRNAs after Pro-Inflammatory Priming

    Investigators analysed the anti-inflammatory properties of umbilical cord MSC-derived extraceullar vesiscles ‘primed’ with pro-inflammatory cytokines, and at baseline with no inflammatory cytokines.
    [Stem Cell Reviews And Reports]

    Full ArticleGraphical Abstract

    Thermosensitive Hydrogel Coupled with Sodium Ascorbyl Phosphate Promotes Human Umbilical Cord-Derived Mesenchymal Stem Cell-Mediated Skin Wound Healing in Mice

    The biological effect of PF-127 hydrogel alone and in combination with SAP on the survival, and migration of cultured human umbilical cord MSCs was assessed by cell viability, apoptosis, and scratch wound assays.
    [Scientific Reports]

    Full Article

    Canine Amniotic Membrane-Derived Mesenchymal Stem Cells Ameliorate Atopic Dermatitis through Regeneration and Immunomodulation

    Canine amnion membrane-MSCs were more effective than oclacitinib in the recovery of wound dysfunction, regulation of mast cell activity, and expression level of immune modulation protein.
    [Veterinary Research Communications]

    Abstract
    Dr. Fabio Rossi discusses the role of mesenchymal stem cells in tissue repair and development.
    REVIEWS

    Modulation of Engineered Nanomaterial Interactions with Organ Barriers for Enhanced Drug Transport

    The authors discuss the recent advances in leveraging nanoparticles to overcome four major biological barriers including the lung mucus, the gastrointestinal mucus, the placental barrier, and the blood–brain barrier.
    [Chemical Society Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    Akari Therapeutics Granted Nomacopan Orphan Drug Designation from the European Commission for Treatment in Hematopoietic Stem Cell Transplantation

    Akari is currently conducting a registrational Phase II study of nomacopan in pediatric hematopoietic stem cell transplant-related thrombotic microangiopathy.
    [Akari Therapeutics]

    Press Release
    FEATURED EVENT

    São Paulo International Symposium

    September 22 – 24, 2023
    Ribeirao Preto, Brazil

    > See All Events

    JOB OPPORTUNITIES

    Research Laboratory Technician – Organoids & Placentation

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Research Laboratory Technician – Placental Research

    University of Cambridge – Cambridge, England, United Kingdom

    Research Associate – Computational Image Analysis for Fetal and Placental Imaging

    King’s College London – London, England, United Kingdom

    Cord Blood Bank – Collector

    Duke University’s Marcus Center for Cellular Cures – Durham, North Carolina, United States

    Research Faculty Position – Placenta Biology & Gynecology

    The Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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