Umbilical & Placental Cell News Volume 15.29 | Aug 3 2023

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    Laurisa Dohm
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    2023-08-03 | UPCN 15.29


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    Vol. 15.29 – 3 August, 2023
    TOP STORY

    PPARγ-Dependent Hepatic Macrophage Switching Acts as a Central Hub for hUCMSC-Mediated Alleviation of Decompensated Liver Cirrhosis in Rats

    The authors performed RNA-seq analysis of liver and primary macrophages and human umbilical cord MSCs co-culture system in vitro to explore possible signaling pathways.
    [Stem Cell Research & Therapy]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    Improved Outcomes of UM171-Expanded Cord Blood Transplantation Compared with Other Graft Sources: Real-World Evidence

    Investigators retrospectively compared results of the Phase I-II trial to those after unmanipulated cord blood and matched unrelated donor transplants.
    [Blood Advances]

    Abstract

    Administration of AG490 Decreases the Senescence of Umbilical Cord-Mesenchymal Stem Cells and Promotes the Cytotherapeutic Effect in Liver Fibrosis

    Researchers uncovered the fate of transplanted MSCs and develop targeting strategies that could enhance the therapeutic efficacy of MSC therapy in liver fibrosis. They used human umbilical cord-MSCs as the study object.
    [Cell Death Discovery]

    Full Article

    Safety and Feasibility of Adjunct Autologous Cord Blood Stem Cell Therapy during the Norwood Heart Operation

    Scientists detailed a Phase I, open label safety and feasibility trial of autologous cord blood stem cells therapy via a novel blood cardioplegia-based intracoronary infusion technique during the Norwood procedure in neonates with antenatal diagnosis of hypoplastic left heart syndrome.
    [Journal of Thoracic and Cardiovascular Surgery]

    Abstract

    A Robust and Standardized Method to Isolate and Expand Mesenchymal Stromal Cells from Human Umbilical Cord

    Using 90 hUC donors, the authors compared and optimized critical variables during each phase of the multi-step procedure involving umbilical cord collection, processing, MSC isolation, expansion, and characterization.
    [Cytotherapy]

    Full ArticleGraphical Abstract

    Human Umbilical Cord-Derived Mesenchymal Stromal Cells Alleviate Liver Cirrhosis through the Hippo/YAP/Id1 Pathway and Macrophage-Dependent Mechanism

    Researchers investigated the effects of human umbilical cord-MSCs on hepatic stellate cells and macrophages by in vitro co-culture experiments.
    [International Immunopharmacology]

    AbstractGraphical Abstract
    Tips to prepare for your next conference or networking event
    REVIEWS

    Volume Electron Microscopy Reveals Placental Ultrastructure in 3D

    The author highlights the potential for volume electron microscopy to advance our understanding of placental ultrastructure.
    [Placenta]

    Full Article
    INDUSTRY AND POLICY NEWS

    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Editorial
    FEATURED EVENT

    5th TIL Therapies Summit

    October 2 – 4, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    Research Laboratory Technician – Organoids & Placentation

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Research Laboratory Technician – Placental Research

    University of Cambridge – Cambridge, England, United Kingdom

    Research Associate – Computational Image Analysis for Fetal and Placental Imaging

    King’s College London – London, England, United Kingdom

    Cord Blood Bank – Collector

    Duke University’s Marcus Center for Cellular Cures – Durham, North Carolina, United States

    > See All Jobs

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