Umbilical & Placental Cell News Volume 15.30 | Aug 10 2023

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    2023-08-10 | UPCN 15.30


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    Vol. 15.30 – 10 August, 2023
    TOP STORY

    MicroRNA Cargo in Wharton’s Jelly MSC Small Extracellular Vesicles: Key Functionality to In Vitro Prevention and Treatment of Premature White Matter Injury

    Researchers isolated MSC from umbilical cord tissue, the Wharton’s jelly, and purified small extracellular vesicles from Wharton’s jelly-MSC culture supernatant by ultracentrifugation and size exclusion chromatography.
    [Stem Cell Reviews And Reports]

    Full Article
    Learn how to optimize genome editing conditions for CD34+ cells, evaluate genome editing efficiency, and much more!
    PUBLICATIONSRanked by the impact factor of the journal

    Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Are Ineffective for Myocardial Repair in an Immunodeficient Rat Model of Chronic Ischemic Cardiomyopathy

    Human Wharton’s Jelly MSCs and bone marrow MSCs were expanded in vitro, characterized, and evaluated for therapeutic efficacy in an immunodeficient rat model of ischemic cardiomyopathy.
    [Stem Cell Reviews And Reports]

    Full Article

    hUC-MSC-EV-miR-24 Enhances the Protective Effect of Dexmedetomidine Preconditioning against Myocardial Ischemia–Reperfusion Injury through the KEAP1/Nrf2/HO-1 Signaling

    Researchers collected and identified human umbilical cord-MSCs and extracted extracellular vesicles, which were co-cultured with dexmedetomidine-preconditioned hypoxia/reoxygenation cardiomyocyte models or injected into ischemic-reperfusion mouse models.
    [Drug Delivery And Translational Research]

    AbstractGraphical Abstract

    Placental Expanded Mesenchymal-Like Cells (PLX-R18) for Poor Graft Function after Hematopoietic Cell Transplantation: A Phase I Study

    PLX-R18, a placental-derived mesenchymal-like cell product, was expanded ex vivo in a 3D environment. This phase I, first-in-human study included 21 patients with incomplete hematopoietic recovery post-hematopoietic cell transplantation, who were treated with escalating doses of PLX-R18.
    [Bone Marrow Transplantation]

    Full Article

    Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Trophoblast Cell Proliferation and Migration by Targeting TFPI2 in Preeclampsia

    Extracellular vesicles derived from human umibilical cord-MSCs enhanced HTR8-S/Vneo cell proliferation and migration.
    [Stem Cells International]

    Full Article

    Effectiveness and Safety of Normoxic Allogenic Umbilical Cord Mesenchymal Stem Cells Administered As Adjunctive Treatment in Patients with Severe COVID-19

    A double-blind, multicentric, randomized, placebo-controlled trial involving severe COVID-19 patients was performed from January to June 2021 in three major hospitals across Java, Indonesia.
    [Scientific Reports]

    Full Article
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Effects of Polycyclic Aromatic Hydrocarbons (PAHs) on Pregnancy, Placenta, and Placental Trophoblasts

    The authors summarize current knowledge on the effects of PAHs and their metabolites on pregnancy and birth outcomes and on placental trophoblast cells.
    [Ecotoxicology And Environmental Safety]

    Full Article

    Umbilical Cord Mesenchymal Stem Cells for Regenerative Treatment of Intervertebral Disc Degeneration

    Scientists focus on the cell source, cell characteristics, mechanism of action, and related experiments to summarize the umbilical cord MSCs, and explore the feasibility of tissue engineering technology of umbilical cord MSCs.
    [Frontiers In Cell And Developmental Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    NIH Researchers Say Agency Seeks to Block Unionization Effort

    Early-career researchers who work in labs operated by the US National Institutes of Health (NIH) have hit a roadblock on their way to unionizing.
    [Science Insider]

    Editorial
    FEATURED EVENT

    The Human Microbiome

    September 20 – 23, 2023
    EMBL Heidelberg and Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellowship – Toxicology/Pharmacology

    US FDA – Silver Spring, Maryland, United States

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    Research Laboratory Technician – Organoids & Placentation

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    Research Associate – Computational Image Analysis for Fetal and Placental Imaging

    King’s College London – London, England, United Kingdom

    Cord Blood Bank – Collector

    Duke University’s Marcus Center for Cellular Cures – Durham, North Carolina, United States

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