Umbilical & Placental Cell News Volume 15.31 | Aug 17 2023

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    2023-08-17 | UPCN 15.31


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.31 – 17 August, 2023
    TOP STORY

    Neutrophil Infiltration Leads to Fetal Growth Restriction by Impairing the Placental Vasculature in DENV-Infected Pregnant Mice

    A mouse inflammation array was used to detect the cytokine and chemokine profiles in the serum and placenta, and the infiltration characteristics of inflammatory cells in the placentas were evaluated by single-cell RNA sequencing.
    [Ebiomedicine]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    The Transcriptional Activator Klf5 Recruits p300-Mediated H3K27ac for Maintaining Trophoblast Stem Cell Pluripotency

    Scientists showed that Klf5 knockdown resulted in downregulation of core trophoblast stem cell-specific genes, consequently causing a rapid differentiation of trophoblast stem cells.
    [Journal Of Molecular Cell Biology]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Alleviate Paclitaxel-Induced Spermatogenesis Defects and Maintain Male Fertility

    An in vivo paclitaxel-induced mice model was constructed to evaluate the reproductive toxicity and protective roles of hUC-MSCs in male fertility improvement.
    [Biological Research]

    Full Article

    Deficiency of HtrA4 in BeWo Cells Downregulates Angiogenesis through IL-6/JAK/STAT3 Signaling

    To explore the role of HtrA4 in angiogenesis, HUVECs were co-cultured with wild-type BeWo cells, BeWo KO, and HtrA4-rescued BeWo KO cells.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    A Novel 3D Biofabrication Strategy to Improve Cell Proliferation and Differentiation of Human Wharton’s Jelly Mesenchymal Stromal Cells for Cell Therapy and Tissue Engineering

    Human Wharton’s jelly MSCs were cultured in 3D using 100%, 75%, 50%, and 25% concentrations of fibrin-agarose biomaterials, and compared with control cells cultured using classical 2D systems.
    [Frontiers In Bioengineering And Biotechnology]

    Full Article

    Safety of Romiplostim Administered Immediately after Cord-Blood Transplantation: A Phase I Trial

    This study included six adults with hematologic malignancies in remission. Romiplostim was administered subcutaneously within seven days after single-unit cord-blood transplantation, then once a week for 14 weeks or until platelet recovery.
    [Annals Of Hematology]

    Abstract
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    REVIEWS

    Therapeutic Effects of Different Intervention Forms of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Osteoarthritis

    The authors review the application of human umbilical cord-MSCs as a treatment for osteoarthritis. With the continuous development of routine clinical applications, more reliable intervention modalities for this treatment will be discovered for the time to come.
    [Frontiers In Cell And Developmental Biology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Brinter Joins RegenMed Hub

    Printer Bio-Implant company joined the RegeneratOR’s Innovation Accelerator in 2023, located in the Regenerative Medicine Hub, a rapidly growing regenerative medicine ecosystem based in the Innovation Quarter, in Winston-Salem.
    [Brinter Bio-Implant (EurekAlert!)]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Ovarian Cancer

    October 5 – 7, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Bioinformatics Scientist – Circulating Trophoblasts Profiling

    RareCyte – Seattle, Washington, United States

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

    Postdoctoral Research Fellowship – Toxicology/Pharmacology

    US FDA – Silver Spring, Maryland, United States

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    Research Laboratory Technician – Organoids & Placentation

    Friedrich Miescher Institute for Biomedical Research – Basel, Switzerland

    > See All Jobs

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