Umbilical & Placental Cell News Volume 15.32 | Aug 24 2023

August 24, 2023

2023-08-24 | UPCN 15.32

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Vol. 15.32 – 24 August, 2023

TOP STORY

Exosomes from TNF-α Preconditioned Human Umbilical Cord Mesenchymal Stromal Cells Inhibit the Autophagy of Acinar Cells of Severe Acute Pancreatitis via Shuttling Bioactive Metabolites

Functional experiments indicated that 3,4-dihydroxyphenylglycol could be a key molecule mediating the therapeutic effect of TNF-α-preconditioned human umbilical cord MSCs.
[Cellular And Molecular Life Sciences]

Abstract

Request your free copy of the 'Bone Marrow Niches and HSC Fates' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Zika Virus Co-Opts miRNA Networks to Persist in Placental Niches Detected by Spatial Transcriptomics

Investigators tested the hypothesis that Zika virus functionally disrupted placental miRNAs, enabling viral persistence and fetal pathogenesis.
[American Journal Of Obstetrics & Gynecology Mfm]

Abstract

hUC-MSC Transplantation Therapy Effects on Lupus-Prone MRL/Lpr Mice at Early Disease Stages

Commercially available human umbilical cord-MSCs were transplanted into eight-week-old MRL/lpr mice by tail vein injection.
[Stem Cell Research & Therapy]

Full Article

Carrageenan as a Macromolecular Crowding Agent in Human Umbilical Cord Derived Mesenchymal Stromal Cell Culture

Scientists evaluated the biophysical properties of seven different carrageenan molecules at five different concentrations and their effect on human umbilical cord-derived MSC morphology, viability, metabolic activity, proliferation, extracellular matrix deposition and surface marker expression.
[International Journal Of Biological Macromolecules]

Full Article

Mucin1 Induced Trophoblast Dysfunction in Gestational Diabetes Mellitus via Wnt/β-Catenin Pathway

In vitro studies were performed using HTR-8/SVneo cells that were cultured and treated with high glucose, sh-MUC1 and FH535, an inhibitor of Wnt/β-catenin signaling.
[Biological Research]

Full Article

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^−/− Mice and Human Intrahepatic Cholangiocyte Organoid Models

Researchers explored the therapeutic potential of human placental MSCs in primary sclerosing cholangitis through the Takeda G protein-coupled receptor 5 (TGR5) receptor pathway.
[Research]

Full Article

Five tips for returning to the lab after time off

REVIEWS

Allogeneic Cell Therapy Applications in Neonates: A Systematic Review

Two authors searcheed various registries for studies investigating the safety, feasibility, and efficacy of allogeneic cell therapy in neonates. The authors independently selected the articles, extracted data, and assessed the risk of bias.
[Stem Cells Translational Medicine]

Full Article

INDUSTRY AND POLICY NEWS

Artiva Biotherapeutics Announces FDA Clearance of IND for AlloNK^® Cell Therapy Candidate in Combination with Rituximab in Lupus Nephritis

AlloNK is a non-genetically modified, cord blood-derived, allogeneic, cryopreserved natural killer cell therapy candidate designed to enhance antibody-dependent cellular cytotoxicity.
[Artiva Biotherapeutics Inc.]

Press Release

FEATURED EVENT

Umbilical & Placental Cell News Volume 15.32 | Aug 24 2023

Exosomes from TNF-α Preconditioned Human Umbilical Cord Mesenchymal Stromal Cells Inhibit the Autophagy of Acinar Cells of Severe Acute Pancreatitis via Shuttling Bioactive Metabolites

Zika Virus Co-Opts miRNA Networks to Persist in Placental Niches Detected by Spatial Transcriptomics

hUC-MSC Transplantation Therapy Effects on Lupus-Prone MRL/Lpr Mice at Early Disease Stages

Carrageenan as a Macromolecular Crowding Agent in Human Umbilical Cord Derived Mesenchymal Stromal Cell Culture

Mucin1 Induced Trophoblast Dysfunction in Gestational Diabetes Mellitus via Wnt/β-Catenin Pathway

Human Placental Mesenchymal Stem Cells Relieve Primary Sclerosing Cholangitis via Upregulation of TGR5 in Mdr2^−/− Mice and Human Intrahepatic Cholangiocyte Organoid Models

Allogeneic Cell Therapy Applications in Neonates: A Systematic Review

Artiva Biotherapeutics Announces FDA Clearance of IND for AlloNK^® Cell Therapy Candidate in Combination with Rituximab in Lupus Nephritis

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