Umbilical & Placental Cell News Volume 15.35 | Sep 14 2023

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    2023-09-13 | UPCN 15.35


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    Vol. 15.35 – 14 September, 2023
    TOP STORY

    Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after Spinal Cord Injury

    Specific subpopulations of CD146+CD271+ umbilical cord MSCs were isolated, from which engineered exosomes with targeted neovascularization function were obtained through gene transfection.
    [ACS Nano]

    AbstractGraphical Abstract
    Dr. Daniel Dever, describes a CRISPR-Cas9-based protocol for gene editing hematopoietic stem cells in this on-demand webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Zika Virus Targets Human Trophoblast Stem Cells and Prevents Syncytialization in Placental Trophoblast Organoids

    Newly developed human trophoblast stem cells (hTSC)-derived trophoblast organoid, researchers demonstrated that Zika virus infection disrupted the structure of mature hTSC-organoids and inhibited syncytialization.
    [Nature Communications]

    Full Article

    Fluid Shear Stress Induces a Shift from Glycolytic to Amino Acid Pathway in Human Trophoblasts

    Placental tissue from pregnancies with intrauterine growth restriction were exposed to high shear rates and showed also decreased glutamic-oxaloacetic transaminase 2, while GLUT1 was unchanged and glycolytic rate-limiting enzymes showed a trend to be upregulated.
    [Cell & Bioscience]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Attenuate Neuroinflammation and Oxidative Stress through the NRF2/NF-κB/NLRP3 Pathway

    The effects of human umbilical cord-MSC-derived exosomes on inflammatory cytokine expression, oxidative stress, and microglia polarization were studied by immunofluorescence and western blotting.
    [CNS Neuroscience & Therapeutics]

    Full Article

    Umbilical Cord Mesenchymal Stem Cells Relieve Osteoarthritis in Rats through Immunoregulation and Inhibition of Chondrocyte Apoptosis

    In vitro experiments showed that co-culturing umbilical cord MSCs (UCMSCs) and chondrocytes promoted the expression of aggrecan, COL2, SOX9, and BCL-2; downregulated the expression of BAX and BAD in chondrocytes; and promoted the expression of IL-10 and TGF-β1 in UCMSCs.
    [Scientific Reports]

    Full Article

    Impact of Administering Umbilical Cord-Derived Mesenchymal Stem Cells to Cynomolgus Monkeys with Endometriosis

    Laparoscopic findings showed exacerbation of endometriosis after intraperitoneal umbilical cord-MSC administration, although no changes were observed in the control group.
    [Reproductive Medicine And Biology]

    Full Article
    Learn how to be a great STEM mentor to new lab members
    REVIEWS

    A New Beginning: Can Omidubicel Emerge As the Next, Viable Alternative Donor Source?

    The authors focus on umbilical cord blood transplantation, benefits and barriers to using this alternative donor source, and finally the potential advancements with incorporation of omidubicel in the transplant setting for malignant and non-malignant diseases.
    [Therapeutic Advances In Hematology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Scientific Sleuths Spot Dishonest ChatGPT Use in Papers

    Many publishers, including Elsevier and Springer Nature, have said that authors can use ChatGPT and other large language model tools to help them produce their manuscripts, as long as they declare it.
    [Nature News]

    Editorial
    FEATURED EVENT

    Advances in Cancer Immunotherapy™: A Focus on Hematologic Malignancies

    October 19, 2023
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    JOB OPPORTUNITIES

    Research Technician – Placental Function

    Leeds Institute of Medical Research – Leeds, England, United Kingdom

    Faculty and Postdoc Positions – iHuman Institute

    ShanghaiTech University – Shanghai, China

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    UT Southwestern Medical Center – Dallas, Texas, United States

    Senior Scientist – Stem Cell Engineering

    Amgen – Burnaby, British Columbia, Canada

    Research Associate – Recombinant Protein

    Creative Biolabs – New York, New York, United States

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