Umbilical & Placental Cell News Volume 15.37 | Sep 28 2023

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    2023-07-28 | UPCN 15.37


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    Vol. 15.37 – 28 September, 2023
    TOP STORY

    Directly Coaxial Bioprinting of 3D Vascularized Tissue Using Novel Bioink Based on Decellularized Human Amniotic Membrane

    The authors developed a novel technique to directly bioprint 3D cell-laden prevascularized construct. They developed a novel bioink by mixing decellularized human amniotic membrane and alginate in various ratios.
    [International Journal Of Biological Macromolecules]

    Abstract

    Banner Ad Cross Reference Banner Ad Cross Reference 100% 10 E17 Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. Screen reader support enabled. Visit the Hematopoiesis Resource Center for videos, tips, and protocols to help with your research questions. Turn on screen reader support
    PUBLICATIONSRanked by the impact factor of the journal

    Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes Assessed by Retrospective Continuous Glucose Monitoring

    In this randomized and placebo-controlled trial, a total of 73 patients were randomly assigned to receive intravenous infusion of umbilical cord-derived mesenchymal stem cells or placebo, three times at four-week intervals and followed up for 48 weeks.
    [Stem Cells Translational Medicine]

    Full ArticleGraphical Abstract

    CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

    The authors established CD34+ cord blood-derived CBFA2T3::GLIS2 models that sustained serial transplantation and recapitulated human leukemia regarding immunophenotype.
    [Blood Advances]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cells Ameliorate Colon Inflammation via Modulation of Gut Microbiota-SCFAs-Immune Axis

    Researchers investigated for the first time the role of gut microbiota in mediating the protective effect of human umbilical cord MSCs on 2% dextran sodium sulfate-induced colitis.
    [Current Stem Cell Research & Therapy]

    Full Article

    Umbilical Cord Mesenchymal Stem Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Cutaneous Wound Healing in Type 2 Diabetic Mice via Macrophage Pyroptosis Inhibition

    Umbilical cord MSCs were cultured in vitro and apoptosis was induced. Apoptotic extracellular vesicles were extracted and identified and used in a type 2 diabetes mellitus mouse cutaneous wound model to evaluate their efficacy.
    [Stem Cell Research & Therapy]

    Full Article

    Successful 3D Culture and Transplantation of Mouse Isolated Preantral Follicles in Hydrogel of Bioengineered Wharton’s Jelly

    Decellularized Wharton’s Jelly was dissolved to make Wharton’s Jelly Hydrogel, and composited with Alginate in equal ratio.
    [PLOS One]

    Abstract
    Scientific resources to support your hematopoiesis research. Learn More!
    REVIEWS

    Meta-Analysis on Last Ten Years of Clinical Injection of Bone Marrow-Derived and Umbilical Cord MSC to Reverse Cirrhosis or Rescue Patients with Acute-on-Chronic Liver Failure

    Investigators conducted a systemic literature review was conducted by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of MSC therapy on the outcomes among patients with end-stage liver disease.
    [Stem Cell Research & Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Advisory Committee Downvotes Mesenchymal Stem Cell Approach NurOwn as Potential ALS Therapy

    The FDA’s Cellular, Tissue, and Gene Therapies Advisory Committee has voted that current data on NurOwn, BrainStorm Cell Therapeutics’ stromal cell therapy, is not sufficient in demonstrating efficacy as a treatment for patients with mild to moderate amyotrophic lateral sclerosis (ALS).
    [NeurologyLive]

    Press Release
    FEATURED EVENT

    The Tumor Landscape: Translating Mechanism to Therapy

    October 29 – November 1, 2023
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    JOB OPPORTUNITIES

    Faculty Positions – Cell Therapies

    University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Reproductive Biology & Gynecological Disease

    Stanford University – Stanford, California, United States

    Faculty and Postdoc Positions – iHuman Institute

    ShanghaiTech University – Shanghai, China

    Assistant Professor – Molecular Biology of Reproduction

    UT Southwestern Medical Center – Dallas, Texas

    Research Associate – Stem Cell Biology-Bioengineering

    University of Cambridge – Cambridge, England, United Kingdom

    > See All Jobs

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