Umbilical & Placental Cell News Volume 15.38 | Oct 5 2023

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    2023-10-05 | UPCN 15.38


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    Vol. 15.38 – 5 October, 2023
    TOP STORY

    Cerium Oxide Nanoparticles-Carrying Human Umbilical Cord Mesenchymal Stem Cells Counteract Oxidative Damage and Facilitate Tendon Regeneration

    Researchers synthesized polyethylene glycol-packed CeONPs (PEG-CeONPs), which were loaded into the human umbilical cord MSCs to counteract oxidative damage.
    [Journal Of Nanobiotechnology]

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    Subconjunctival Injection of Human Umbilical Cord Mesenchymal Stem Cells Alleviates Experimental Allergic Conjunctivitis via Regulating T Cell Response

    Scientists elucidated the therapeutic effect and mechanism of the human umbilical cord MSCs in a mouse model of experimental allergic conjunctivitis.
    [Stem Cell Research & Therapy]

    Full Article

    Human Umbilical Cord-Derived Mesenchymal Stem Cells (hUC-MSCs) Alleviate Excessive Autophagy of Ovarian Granular Cells Through VEGFA/PI3K/AKT/mTOR Pathway in Premature Ovarian Failure Rat Model

    The ovarian function was evaluated by ovarian morphology, histology, estrous cycle, hormone levels, and fertility ability to investigate the effect of human umbilical cord-MSCs on the premature ovarian failure rats model.
    [Journal Of Ovarian Research]

    Full Article

    A Pilot Study of Cord Blood-Derived Natural Killer Cells As Maintenance Therapy After Autologous Hematopoietic Stem Cell Transplantation

    Investigators expanded cord blood-derived natural killer (CB-NK) cells ex vivo from random donors and investigated the feasibility and efficacy of repeated infusions CB-NK cells as maintenance therapy after autologous hematopoietic stem cell transplantation.
    [Annals Of Hematology]

    Abstract

    Design and Fabrication of Gelatin-Based Hydrogel Loaded with Modified Amniotic Extracellular Matrix for Enhanced Wound Healing

    Researchers employed decellularized human amniotic membrane (dHAM) as a bioactive ECM and modified it through methacrylate grafting for engineering purposes, resulting in the photosensitive dECMMA.
    [Heliyon]

    Full Article

    Human Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Perioperative Neurocognitive Disorder by Inhibiting Inflammatory Responses and Activating BDNF/TrkB/CREB Signaling Pathway in Aged Mice

    Human umbilical cord-MSCs were isolated from an infant umbilical cord and identified using flow cytometry and differentiation assays. Scientists established perioperative neurocognitive disorder model by undergoing aseptic laparotomy under isoflurane anesthesia maintaining spontaneous ventilation.
    [Current Stem Cell Research & Therapy]

    Full Article
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    REVIEWS

    Mesenchymal Stem Cells and Their Derived Exosomes for ALI/ARDS: A Promising Therapy

    The emergence of MSCs and their exosomes has opened up an expansive realm of potential and optimism for addressing the plight of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) patients, as MSCs and their derived exosomes exhibited multifaceted capabilities.

    Full Article
    INDUSTRY AND POLICY NEWS

    Expecting Extremes: Intense Heat is a Particular Hazard in Pregnancy

    Starting soon, dozens of pregnant women will be pedaling in a “climate chamber”, high-ceilinged room heated to high temperatures. The groundbreaking study seeks to replicate what tens of millions of pregnant people experience every day in a warming world: physical exertion in intense heat.
    [Science Magazine]

    Press Release
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