Umbilical & Placental Cell News Volume 15.39 | Oct 12 2023

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    2023-05-12 | UPCN 15.39


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    Vol. 15.39 – 12 October, 2023
    TOP STORY

    The Maternal Microbiome Promotes Placental Development in Mice

    Researchers showed that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricted placental growth and impaired feto-placental vascularization.
    [Science Advances]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    α1,3-Fucosylation of MEST Promotes Invasion Potential of Cytotrophoblast Cells by Activating Translation Initiation

    The authors discovered the decreased α1,3-fucosylation, especially difucosylated Lewis Y (LeY) glycan, in the villus tissues of miscarriage patients when compared with normal pregnancy women.
    [Cell Death & Disease]

    Full Article

    Fabrication and Optimization of Multilayered Composite Scaffold Made of Sulfated Alginate-Based Nanofiber/Decellularized Wharton’s Jelly ECM for Tympanic Membrane Tissue Engineering

    Investigators fabricated a novel multilayer polyvinyl alcohol/alginate sulfate nanofiber/decellularized Wharton’s Jelly extracellular matrix composite for tympanic membrane perforations tissue engineering.
    [International Journal Of Biological Macromolecules]

    AbstractGraphical Abstract

    Bioprocess Development for Cord Blood Mesenchymal Stromal Cells on Microcarriers in Vertical-Wheel Bioreactors

    Researchers investigated the development of an expansion process using Vertical-Wheel bioreactors, a single-use bioreactor technology that incorporates a wheel instead of an impeller.
    [Biotechnology And Bioengineering]

    Full Article

    Biocompatible Human Placental Extracellular Matrix Derived Hydrogels

    Hydrogels were prepared by decellularization of human placental tissue using detergent and enzymes and by the subsequent creation of a homogenized acellular placental tissue powder.
    [Advanced Biology]

    Abstract

    Nervonic Acid Inhibits Replicative Senescence of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

    The authors identified novel metabolites that regulate the replicative senescence in MSCs. Using a fecal metabolites library, they identified nervonic acid as a candidate metabolite for replicative senescence regulation.
    [International Journal Of Stem Cells]

    Abstract
    Cell Preparation For Crossmatch Assays
    REVIEWS

    A Comprehensive Review of Human Trophoblast Fusion Models: Recent Developments and Challenges

    Scientists review the existing models employed for the investigation of human trophoblast fusion from several aspects, including the development history, latest progress, advantages, disadvantages, scope of application, and challenges.
    [Cell Death Discovery]

    Full ArticleGraphical Abstract

    Progress in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy with Umbilical Cord Blood Mononuclear Cells

    Investigators focus on safety and efficacy, the route of administration, dose, timing, and combination treatment of cord blood-derived mononuclear cells in hypoxic-ischemic encephalopathy.
    [Brain & Development]

    Abstract
    INDUSTRY AND POLICY NEWS

    WHO Issues Global Plan to Tackle Leading Cause of Death in Childbirth

    WHO released its first roadmap to tackle postpartum hemorrhage – defined as excessive bleeding after childbirth – which affects millions of women annually and is the world’s leading cause of maternal deaths.
    [World Health Organization]

    Press Release
    FEATURED EVENT

    AACR-KCA Joint Conference on Precision Medicine in Cancer

    November 15 – 17, 2023
    Seoul, Korea

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    JOB OPPORTUNITIES

    Licensing Manager – Human Uterus in Pregnancy and Disease

    Centre for Trophoblast Research – Cambridge, England, United Kingdom

    Research Associate – Developmental Biology

    Mount Saint Vincent University – Halifax, Nova Scotia, Canada

    Faculty Positions – Cell Therapies

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Position – Reproductive Biology & Gynecological Disease

    Stanford University – Stanford, California, United States

    Postdoctoral Research Fellow – Organic Materials for Next Generation Bioelectronic Devices

    The Leibniz Institute of Polymer Research Dresden – Dresden, Germany

    > See All Jobs

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