Umbilical & Placental Cell News Volume 15.43 | Nov 16 2023

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    2023-11-16 | UPCN 15.43


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.43 – 16 November, 2023
    TOP STORY

    Modeling the Progression of Placental Transport from Early- to Late-Stage Pregnancy by Tuning Trophoblast Differentiation and Vascularization

    Predictive models of early- and late-stage placental transport were created using blastocyst-derived placental stem cells (PSCs) by modulating PSC differentiation and model vascularization.
    [Advanced Healthcare Materials]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Mesenchymal Stem Cell-Derived Mitochondria Enhance Extracellular Matrix-Derived Grafts for The Repair of Nerve Defect

    High-purity functional mitochondria with an intact structure were extracted from human umbilical cord-derived MSCs using the Dounce homogenization combined with ultracentrifugation.
    [Advanced Healthcare Materials]

    Abstract

    Human Amniotic Membrane-Derived Mesenchymal Stem Cells Prevent Acute Graft-Versus-Host Disease in an Intestinal Microbiome-Dependent Manner

    The preventive effects of human amniotic membrane-derived MSC was assessed in humanized acute graft-versus-host disease models. Immunohistochemistry and RT-qPCR were used to evaluate intestinal barrier function.
    [Transplantation And Cellular Therapy]

    Full Article

    The Influence of Insulin-Related Genetic Variants on Fetal Growth, Fetal Blood Flow, and Placental Weight in a Prospective Pregnancy Cohort

    Investigators explored the fetal insulin hypothesis theory further by testing the effects of GWAS-identified genetic variants related to insulin release and sensitivity on fetal growth and blood flow from week 20 of gestation to birth and on placental weight at birth.
    [Scientific Reports]

    Full Article

    Inhibition of Lipopolysaccharide-Induced Inflammation by Trophoblast-Conditioned Medium and Trophoblast-Derived Extracellular Vesicles in Human Middle Ear Epithelial Cells

    Researchers elucidated the inflammation-inhibiting efficacy of conditioned medium and extracellular vesicles derived from human trophoblast cells in lipopolysaccharide-induced human middle ear epithelial cells.
    [Scientific Reports]

    Full Article

    Human Umbilical Cord Mesenchymal Stem Cells Repair Endothelial Injury and Dysfunction by Regulating NLRP3 to Inhibit Endothelial Cell Pyroptosis in Kawasaki Disease

    The authors examined whether human umbilical cord-MSCs inhibited endothelial inflammation and improved endothelial function in Kawasaki disease (KD) through constructing cell and in vivo animal KD vasculitis models.
    [Inflammation]

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    REVIEWS

    Clinical Application of Umbilical Cord Mesenchymal Stem Cells Preserves β-Cells in Type 1 Diabetes

    Investigators propose prospective mechanisms of action of Wharton’s jelly-MSCs that may be mediating their observed capability to preserve β-cell function and prevent type 1 diabetes progression and provide recommendations for further investigations in clinical settings.
    [Stem Cells Translational Medicine]

    Full Article
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    Abstract
    INDUSTRY AND POLICY NEWS

    Mirvie Announces Completion of Enrollment of 10,000 Person Landmark Research Study for Pregnancy Health

    ‍Mirvie announced the completion of enrollment of its landmark 10,000 person research study for pregnancy health, in collaboration with leading experts in obstetrics and maternal-fetal medicine.
    [Mirvie]

    Press Release
    FEATURED EVENT

    3rd Neurogenesis Conference

    February 8 – 11, 2024
    Cancun, Mexico

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    JOB OPPORTUNITIES

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States

    Assistant Project Scientist – Mesenchymal Progenitor Cells

    University of California – Los Angeles, California, United States

    Laboratory Director – Biobank

    Baylor College of Medicine – Houston, Texas, United States

    Research Assistant – MSC Biofactories

    National University of Singapore – Singapore, Singapore

    Postdoctoral Researcher – Cancer Immunology and Immunotherapy

    University of Turku – Turku, Finland

    > See All Jobs

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