Umbilical & Placental Cell News Volume 15.45 | Nov 30 2023

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    2024-11-30 | UPCN 15.45


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    Vol. 4.30 – 30 November, 2023
    TOP STORY

    Placental Streptococcus agalactiae DNA Is Associated with Neonatal Unit Admission and Fetal Pro-Inflammatory Cytokines in Term Infants

    The authors re-analyzed a dataset which detected Streptococcus agalactiae DNA in the placenta in ~5% of women before the onset of labour as a case control study of neonatal unit admission.
    [Nature Microbiology]

    Full ArticlePress Release
    Request a free wallchart on the roles of exosomes in the therapeutic effects imparted by mesenchymal stromal cells.
    PUBLICATIONSRanked by the impact factor of the journal

    TNF-α and IFN-γ Prestimulation Enhances the Therapeutic Efficacy of Human Amniotic Epithelial Stem Cells in Chemotherapy-Induced Ovarian Dysfunction

    Researchers observed the pathological changes of the ovaries at different time points during chemotherapy, including the number of follicles, granulosa cell proliferation, oxidative stress damage, ovarian fibrosis, and inflammatory reaction.
    [Inflammation And Regeneration]

    Full ArticleGraphical Abstract

    Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Provide Neuroprotection in Traumatic Brain Injury through the lncRNA TUBB6/Nrf2 Pathway

    Investigators found that administration of human umbilical cord MSC-exosome suppressed traumatic brain injury-induced inflammation and ferroptosis.
    [Brain Research]

    AbstractGraphical Abstract

    Cord Blood Stem Cell-Derived Angptl7 Ameliorates the Severity of Bronchopulmonary Dysplasia via Anti-Inflammatory and Proangiogenic Effects

    The authors compared Angptl7 levels between the autologous cord blood mononuclear cells infusion and control groups. Subsequently, the association between cord blood Angptl7 levels and bronchopulmonary dysplasia incidence in a cohort of very preterm neonates was assessed.
    [Molecular Medicine Reports]

    Abstract

    Human Placental Extract Suppresses Mast Cell Activation and Induces Mast Cell Apoptosis

    To investigate the effects of HPE on the regulation of allergy with respect to the biological functions of mast cells, the mast cell line C57 or HMC-1 cells were treated with HPE followed by the assessment of cell proliferation, apoptosis, activation, chemotaxis and phagocytosis.
    [Allergy Asthma And Clinical Immunology]

    Full Article

    Banked Term Umbilical Cord Blood to Meet the Packed Red Blood Cell Transfusion Needs of Extremely-Low-Gestational-Age Neonates: A Feasibility Analysis

    Researchers retrospectively analyzed all ELGANs RBC Tx over the past three years, estimated local cord blood availability, and assesed interest in this project, and implementation barriers, through stakeholder surveys.
    [Journal Of Perinatology]

    Abstract
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    REVIEWS

    Stem Cell-Based Interventions for the Treatment of Stroke in Newborn Infants

    To evaluate the benefits and harms of stem cell‐based interventions for the treatment of stroke in newborn infants compared to control or stem‐cell based interventions of a different type or source.
    [Cochrane Database Of Systematic Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    Most Clinical Trials Run in Canada Failed to Take Basic Steps Toward Transparency, Analysis Finds

    Just 3% of more than 3,700 studies run exclusively in Canada over a recent 10-year period were registered prospectively, reported results, and published the findings, underscoring ongoing concerns about clinical trial transparency, according to a new analysis.
    [STAT News]

    Full Article
    FEATURED EVENT

    6th DNA Repair/Replication Structures and Cancer Conference

    February 14 – 18, 2024
    Cancun, Mexico

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    JOB OPPORTUNITIES

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    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    PhD Position – Expanding Blood Stem Cells

    University of York – York, England, United Kingdom

    Postdoctoral Researcher – Haematopoietic Stem Cell Biology

    University of York – York, England, United Kingdom

    Research Associate – Cell Biology R&D

    Applied Stem Cell – Milpitas, California, United States

    Assistant Project Scientist – Mesenchymal Progenitor Cells and Perivascular Stem Cells

    University of California, Los Angeles – Los Angeles, California, United States

    > See All Jobs

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