Umbilical & Placental Cell News Volume 15.47 | Dec 14 2023

    By
    lbeveridge
    -
    0
    12








    2023-11-14 | UPCN 15.47


    Umbilical-and-Placental-Cell-News-email-header (1)
    Vol. 15.47 – 14 December, 2023
    TOP STORY

    GDF15 Linked to Maternal Risk of Nausea and Vomiting During Pregnancy

    Using mass spectrometry to detect a naturally-labelled GDF15 variant researchers demonstrated that the vast majority of GDF15 in the maternal plasma was derived from the feto-placental unit.
    [Nature]

    AbstractPress Release
    Kevin Shoulars found a faster, more reproducible way to assess the potency of core blood units for transplant. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    CRISPR Screening in Human Trophoblast Stem Cells Reveals Both Shared and Distinct Aspects of Human and Mouse Placental Development

    Investigators performed CRISPR knockout screening in human trophoblast stem cells (hTSCs). They targeted genes essential for mouse placental development and identified more than 100 genes as critical regulators in both human hTSCs and mouse placentas.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Umbilical Cord Mesenchymal Stromal Cells in Serum-Free Defined Medium Display an Improved Safety Profile

    Performed a comprehensive investigation of the toxicity, immunogenicity and biodistribution of intraperitoneally umbilical cord MSCs derived using serum-free, xeno-free, and chemically defined media.
    [Stem Cell Research & Therapy]

    Full Article

    Maintenance of the Synergistic Effects of Cord Blood Cells and Erythropoietin Combination Therapy After Additional Cord Blood Infusion in Children with Cerebral Palsy: 1-Year Open-Label Extension Study of Randomized Placebo-Controlled Trial

    A one-year open-label extension study aimed to identify the persistent synergistic effects of allogeneic umbilical cord blood cells and erythropoietin in children with cerebral palsy for up to two years.
    [Stem Cell Research & Therapy]

    Full Article

    Tissue-Specific Populations From Amniotic Fluid-Derived Mesenchymal Stem Cells Manifest Variant In Vitro and In Vivo Properties

    Researchers found that the amniotic fluid derived MSCs (AFMSCs) could be categorized into three distinct groups: kidney-specific AFMSCs, lung-specific AFMSCs, and AFMSCs with an undefined tissue source.
    [Human Cell]

    Full Article

    Umbilical Cord-Derived Mesenchymal Stem Cell Sheets Transplanted Subcutaneously Enhance Cell Retention and Survival More than Dissociated Stem Cell Injections

    Scientists compared human umbilical cord (hUC)-MSC in vivo engraftment efficacy and cytokine expression for both hUC-MSC sheets and cell suspensions.
    [Stem Cell Research & Therapy]

    Abstract

    Mesenchymal Stromal Cells Secretome Restores Bioenergetic and Redox Homeostasis in Human Proximal Tubule Cells After Ischemic Injury

    Researchers employed an in vitro model of chemically induced ischemia using antimycin A combined with 2-deoxy-D-glucose to induce ischemic injury in proximal tubule epithelial cells.
    [Current Stem Cell Research & Therapy]

    Full Article
    Ready-to-use, ethically sourced cryopreserved human PB pan-T cells. Click to learn more.
    REVIEWS

    Mitochondrial-Targeted Antioxidant Attenuates Preeclampsia-Like Phenotypes Induced by Syncytiotrophoblast-Specific Gαq Signaling

    Investigators present data supporting increased Gαq signaling and antioxidant responses within villous and syncytiotrophoblast samples of human preeclamptic placenta.
    [Science Advances]

    Full ArticlePress Release
    INDUSTRY AND POLICY NEWS

    A Better Way To Grow Stem Cells

    Dr. Sebastián Vega, an assistant professor of biomedical engineering at Rowan University, is investigating why stem cells lose their identity outside the body, as well as new ways to grow such cells in the lab.
    [Rowan University]

    Press Release

    More Than 10,000 Research Papers Were Retracted in 2023 — A New Record

    The number of retractions issued for research articles in 2023 has passed 10,000 — smashing annual records — as publishers struggle to clean up a slew of sham papers and peer-review fraud.
    [Nature News]

    Press Release
    FEATURED EVENT

    Tandem Meetings Transplantation & Cellular Therapy Meetings of ASTCT® and CIBMTR®

    February 21 – 24, 2024
    San Antonio, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Doctoral Training – Mesenchymal Stromal Cell Therapy

    University of Nottingham – Nottingham, Scotland, United Kingdom

    Associate Professor – Pediatric Hematology/Oncology

    Dalhousie University – Halifax, Nova Scotia, Canada

    Postdoctoral Scientist – Corneal Regenerative Medicine

    Cedars-Sinai Board – Anaheim, California, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    PhD Position – Expanding Blood Stem Cells

    University of York – York, England, United Kingdom

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2