Umbilical & Placental Cell News Volume 16.01 | Jan 11 2024

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    2024-01-11 | UPCN 16.02


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    Vol. 16.01 – 11 January, 2024
    TOP STORY

    Palmitate Induces Integrated Stress Response and Lipoapoptosis in Trophoblasts

    The authors hypothesized that palmitate induces integrated stress response by activating mitogen-activated protein kinases, endoplasmic reticulum stress, and granular stress, and lipoapoptosis in trophoblasts.
    [Cell Death & Disease]

    Full Article
    Image of erythroblasts which were simply & efficiently generated from PSCs using the STEMdiff Erythroid Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia Is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216

    Investigators established CD34+ cord blood–derived CBFA2T3::GLIS2models that sustained serial transplantation and recapitulated human leukemia regarding immunophenotype, leukemia-initiating cell frequencies, comutational landscape.
    [Blood Advances]

    Full Article
    Graphical Abstract

    Methylation of Serotonin Regulating Genes in Cord Blood Cells: Association with Maternal Metabolic Parameters and Correlation with Methylation in Peripheral Blood Cells during Childhood and Adolescence

    Scientists investigated associations between maternal metabolic parameters—pre-pregnancy body mass index, gestational weight gain, and glucose tolerance status, i.e., gestational diabetes mellitus versus normal glucose tolerance.
    [Clinical Epigenetics]

    Full Article

    Efficacy of IFN-γ-Primed Umbilical Cord-Derived Mesenchymal Stem Cells on Temporomandibular Joint Osteoarthritis

    Researchers analyzed changes in the expression of several key genes associated with osteoarthritis protection in MSC-secreted compounds.
    [Tissue Engineering And Regenerative Medicine]

    Abstract

    Single-Cell RNA Sequencing Reveals Association of Aberrant Placental Trophoblasts and FN1 Reduction in Late-Onset Fetal Growth Restriction

    Single-cell RNA sequencing was performed on the maternal side of placentas from two normal pregnant women and two pregnant women with FGR. Lentivirus transfection was used to establish a FN1 knockout model in trophoblast HTR-8-Svneo cells.
    [Placenta]

    Full Article

    Pneumoprotein CC16 in the Umbilical Cord Blood of Preterm Neonates

    Investigators examined the impact of perinatal factors on cord serum club cell protein (CC16) and the association of CC16 with mechanical ventilation and bronchopulmonary dysplasia in preterm neonates.
    [American Journal Of Perinatology]

    Abstract
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Harnessing the Therapeutic Potential of Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles as a Novel Cell-Free Therapy for Animal Models of Multiple Sclerosis

    Scientists explored the existing literature on the effects of MSC-extracellular vesicles in animal models of multiple sclerosis .
    [Experimental Neurology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Aegle Therapeutics Corp. Announces Positive Data for the First Patient in a Phase I/IIa Clinical Trial Dosed With AGLE-102â„¢, a Novel Extracellular Vesicle Therapy

    Aegle Therapeutics Corp. announced positive 12-week data for the first patient enrolled in a Phase I/IIa clinical trial of AGLE-102â„¢ for the treatment of severe second-degree burns.
    [Aegle Therapeutics Corp (PR Newswire)]

    Press Release
    FEATURED EVENT

    London Biotechnology Show 2024

    February 27 – 28, 2024
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Assistant – Mammal Limb Regeneration

    University of Cambridge – Cambridge, England, United Kingdom

    Doctoral Training – Mesenchymal Stromal Cell Therapy

    University of Nottingham – Nottingham, Scotland, United Kingdom

    Principal Investigators – Human Cell Lineage Atlas Facility

    Guangzhou Institutes of Biomedicine and Health – Guangzhou, China

    Postdoctoral Scientist – Corneal Regenerative Medicine

    Cedars-Sinai Board – Anaheim, California, United States

    Assistant Professor – Stem Cells and Regenerative Medicine

    Ottawa Hospital Research Institute – Ottawa, Ontario, Canada

    > See All Jobs

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