 | | Vol. 16.03 – 25 January, 2024 |
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| Investigators conducted integrated single-nucleus RNA sequencing and single-nucleus ATAC sequencing analyses of human placentas from early and late pregnancy.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified a uterine natural killer (uNK) cell-derived cytokine signal that promoted trophoblast differentiation at the late stage of the invasive pathway.
[Cell Stem Cell] |
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| The authors selected polystyrene nanoplastics (PS-NPs) as a model of plastic particles and treated human trophoblast cells and pregnant mice with PS-NPs at doses near the actual environmental exposure doses of plastic particles in humans.
[ACS Nano] |
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| Scientists investigated whether nirmatrelvir crossed the blood-placenta barrier to reach the conceptus during pregnancy and the blood–brain barrier in male rats.
[npj Viruses] |
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| By screening 1639 chemicals, researchers found that an inhibitor of integrated stress response, ISRIB, could replace WNT agonists and TGFβ inhibitors to maintain the stemness and differentiation capacity of human trophoblast stem cells.
[Cell Proliferation] |
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| Scientists found that the microbiota of pregnant individuals changes in the third trimester. The placental microbiota had its own specific dominant microbiota.
[Heliyon] |
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| Investigators explored the effects of human umbilical cord-derived exosome MSCs on preeclampsia (PE)-like models. Lipopolysaccharide was used to construct in vitro and in vivo PE-like models.
[Heliyon] |
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| In the uterus, TAS2Rs contribute to uterine relaxation and hold potential as therapeutic targets for preventing preterm birth. In the placenta, they are proposed to function as vigilant sentinels, responding to infection and potentially modulating mechanisms of fetal protection.
[Journal Of Cellular Physiology] |
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| A Mayo Clinic research experiment will be part of a payload that launches into space from NASA’s Kennedy Space Center in Cape Canaveral, Florida, on January 29, subject to weather conditions and other factors.
[Phys.org] |
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| March 11 – 13, 2024
Lisbon, Portugal |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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| | University of Southampton – Southampton, England, United Kingdom |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | Ottawa Hospital Research Institute – Ottawa, Ontario, Canada |
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