 | | Vol. 16.05 – 8 February, 2024 |
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| Researchers described the generation of trophoblast organoids using human trophoblast stem (TS) cells. Following treatment with three kinds of culture medium, TS cells form spherical organoids with a single outer layer of syncytiotrophoblast cells that displayed a barrier function.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists conducted a systematic drug screen using an epigenetic compound library to systematically investigate the epigenetic mechanism essential for syncytialization, and identified mixed lineage leukemia 1 (MLL1), a histone 3 lysine 4 methyltransferase, as a crucial regulator of trophoblast syncytialization.
[BMC Medicine] |
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| Investigators explored the functional restoration and mechanism of human umbilical cord MSC exosomes on busulfan-induced injury in GC-1 spg cells and ICR mouse testes.
[Ecotoxicology And Environmental Safety] |
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| The authors explored the potential application of human cord blood derived-multipotent stem cells to control donor alloreactive responses involved in allogeneic hematopoietic cell transplantation, which often results in acute graft-vs-host disease.
[Transplantation And Cellular Therapy] |
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| Researchers explored plasma proteins as potential diagnostic biomarkers for placenta accreta spectrum. Integrated transcriptome and proteomic analyses were conducted to establish a novel diagnostic approach.
[Scientific Reports] |
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| By analyzed a group of 230 women who went through pregnancy interruption and comparing those experiencing spontaneous early pregnancy loss (EPL) with a group of normal pregnant who underwent voluntary interruption.
[Scientific Reports] |
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| In vitro, human umbilical cord MSCs were cultured and induced to differentiate into neuron-like cells after they were pretreated with 150 μg/mL monosialoteterahexosyl ganglioside.
[Experimental Cell Research] |
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| Investigators evaluated the therapeutic efficacy of human umbilical cord-MSCs in C57BL/6 mice with diet-induced non-alcoholic steatohepatitis (NASH). At week 32, mice were randomized into two groups: phosphate-buffered saline and MSCs, which were injected into the tail vein.
[Heliyon] |
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 | | | The authors systematically examine the most extensively researched MSC-derived EVs for treating osteoporosis (OP), delving not only into the molecular mechanisms of EV-based OP therapy but also conducting a comparative analysis of the strengths and limitations of EVs sourced from various cell origins.
[Cell Death & Disease] |
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| A research-technology firm has developed a new approach to help identify journal articles that originate from paper mills — companies that churn out fake or poor-quality studies and sell authorships.
[Nature News] |
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| March 18 – 19, 2024
London, England, United Kingdom |
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| | University of Maryland Baltimore – Baltimore, Maryland, United States |
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| | Rutgers, New Jersey Medical School – Newark, New Jersey, United States |
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| | The University of Manchester – Manchester, England, United Kingdom |
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| | Human Technopole – Milan, Italy |
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| | University of Southampton – Southampton, England, United Kingdom |
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