| Vol. 16.06 – 15 February, 2024 |
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| Single-cell RNA sequencing was applied to decipher maternal-fetal signaling in the human placenta during term labor. A single-cell atlas of the human placenta was established, demonstrating that maternal and fetal cell types underwent changes in transcriptomic activity during labor. [Science Translational Medicine] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| By analyzing dynamic changes in transcriptome and enhancer profile during human trophoblast stem cell to extravillous trophoblast differentiation, researchers defined stage-specific regulators, including an early-stage transcription factor, TFAP2C, and multiple late-stage transcription factors. [Nature Communications] |
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| Using single-cell transcriptomics, scientists evaluated how organoids derived from freshly isolated first-trimester trophoblasts or from established uman trophoblast stem cell lines reproduce developmental cell trajectories and transcriptional regulatory processes defined in vivo. [Developmental Cell] |
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| An injectable hydrogel loaded with human umbilical cord-derived MSCs was synthesized via the Diels-Alder click reaction for endometrial regeneration and fertility restoration, exhibiting suitable mechanical properties, good biocompatibility, and desirable degradation properties. [Acta Biomaterialia] |
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| Scientists determined whether thyroid hormones TSH and fT4 are related to the telomere length, mitochondrial DNA copy number, and oxidative stress resistance marker GPX in the cord blood of newborns. [Scientific Reports] |
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| A prospective observational multicenter study including pregnant women with a positive RT-PCR or a positive serology for SARS-CoV-2 and compatible symptoms, from April to December 2020, in 11 French maternities [Scientific Reports] |
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| A hydrogel prepared from decellularized human umbilical cord tissue was developed and evaluated for osteochondral regeneration. MSCs isolated from the umbilical cord were seeded with hydrogel for 28 days, and cell-hydrogel composites were cultured in basal and osteogenic media. [Cell Biology International] |
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| The authors show that studies continue to abound regarding the characterization of MSCs to distinguish them from other similar cell types, the discovery of new tissue sources of MSCs, and the confirmation of their properties and functions that render them suitable as a therapeutic. [Cryobiology] |
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| The University of Liverpool has launched a new spin-out company, TrophiCell, that has developed a revolutionary approach to harness the therapeutic potential of adult MSCs. [University of Liverpool] |
| | While training for the upcoming mission was underway, two NASA Flight Engineers, Jasmin Moghbeli and Loral O’Hara, focused a majority of their day on the Mesenchymal Stem Cells in Microgravity Induced Bone Loss (MABL-A) investigation. [NASA Space Station] |
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| April 4 – 5, 2024 Cincinnati, Ohio, United States |
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| University of Amsterdam – Amsterdam, Netherlands |
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| University of Maryland Baltimore – Baltimore, Maryland, United States |
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| Rutgers, New Jersey Medical School – Newark, New Jersey, United States |
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| The University of Manchester – Manchester, England, United Kingdom |
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| Human Technopole – Milan, Italy |
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