Umbilical & Placental Cell News Volume 16.06 | Feb 15 2024

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    2024-02-15 | UPCN 16.06


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    Vol. 16.06 – 15 February, 2024
    TOP STORY

    Deciphering Maternal-Fetal Cross-Talk in the Human Placenta during Parturition Using Single-Cell RNA Sequencing

    Single-cell RNA sequencing was applied to decipher maternal-fetal signaling in the human placenta during term labor. A single-cell atlas of the human placenta was established, demonstrating that maternal and fetal cell types underwent changes in transcriptomic activity during labor.
    [Science Translational Medicine]

    AbstractPress Release
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    The Transcriptional Regulatory Network Modulating Human Trophoblast Stem Cells to Extravillous Trophoblast Differentiation

    By analyzing dynamic changes in transcriptome and enhancer profile during human trophoblast stem cell to extravillous trophoblast differentiation, researchers defined stage-specific regulators, including an early-stage transcription factor, TFAP2C, and multiple late-stage transcription factors.
    [Nature Communications]

    Full Article

    Single-Cell Assessment of Primary and Stem Cell-Derived Human Trophoblast Organoids as Placenta-Modeling Platforms

    Using single-cell transcriptomics, scientists evaluated how organoids derived from freshly isolated first-trimester trophoblasts or from established uman trophoblast stem cell lines reproduce developmental cell trajectories and transcriptional regulatory processes defined in vivo.
    [Developmental Cell]

    AbstractGraphical Abstract

    Minimally Invasive Delivery of Human Umbilical Cord-Derived Mesenchymal Stem Cells by an Injectable Hydrogel via Diels–Alder Click Reaction for the Treatment of Intrauterine Adhesions

    An injectable hydrogel loaded with human umbilical cord-derived MSCs was synthesized via the Diels-Alder click reaction for endometrial regeneration and fertility restoration, exhibiting suitable mechanical properties, good biocompatibility, and desirable degradation properties.
    [Acta Biomaterialia]

    Full ArticleGraphical Abstract

    Umbilical Cord Blood Thyroid Hormones Are Inversely Related to Telomere Length and Mitochondrial DNA Copy Number

    Scientists determined whether thyroid hormones TSH and fT4 are related to the telomere length, mitochondrial DNA copy number, and oxidative stress resistance marker GPX in the cord blood of newborns.
    [Scientific Reports]

    Full Article

    Analysis of the Transplacental Transmission of SARS CoV-2 Virus and Antibody Transfer According to the Gestational Age at Maternal Infection

    A prospective observational multicenter study including pregnant women with a positive RT-PCR or a positive serology for SARS-CoV-2 and compatible symptoms, from April to December 2020, in 11 French maternities
    [Scientific Reports]

    Full Article

    3D Bio Scaffold Support Osteogenic Differentiation of Mesenchymal Stem Cells

    A hydrogel prepared from decellularized human umbilical cord tissue was developed and evaluated for osteochondral regeneration. MSCs isolated from the umbilical cord were seeded with hydrogel for 28 days, and cell-hydrogel composites were cultured in basal and osteogenic media.
    [Cell Biology International]

    Abstract
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    REVIEWS

    Unraveling MicroRNA Regulation and miRNA–mRNA Regulatory Networks in Osteogenesis Driven by 3D Nanotopographical Cues

    The authors show that studies continue to abound regarding the characterization of MSCs to distinguish them from other similar cell types, the discovery of new tissue sources of MSCs, and the confirmation of their properties and functions that render them suitable as a therapeutic.
    [Cryobiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    New University Spin-Out Developing Novel Adult Stem Cell-Based Therapies

    The University of Liverpool has launched a new spin-out company, TrophiCell, that has developed a revolutionary approach to harness the therapeutic potential of adult MSCs.
    [University of Liverpool]

    Press Release

    Crew Conducts Stem Cell Research and Training as Cargo Craft Nears Launch

    While training for the upcoming mission was underway, two NASA Flight Engineers, Jasmin Moghbeli and Loral O’Hara, focused a majority of their day on the Mesenchymal Stem Cells in Microgravity Induced Bone Loss (MABL-A) investigation.
    [NASA Space Station]

    Editorial
    FEATURED EVENT

    2024 Cincinnati International Symposium

    April 4 – 5, 2024
    Cincinnati, Ohio, United States

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Placenta-Brain Axis

    University of Amsterdam – Amsterdam, Netherlands

    Postdoctoral Position – Red Blood Cell Signaling and Physiology

    University of Maryland Baltimore – Baltimore, Maryland, United States

    Faculty Positions – Obstetrics, Gynecology and Reproductive Health

    Rutgers, New Jersey Medical School – Newark, New Jersey, United States

    Research Associate – Maternal & Fetal Health

    The University of Manchester – Manchester, England, United Kingdom

    Technician – Tissue and Organoid Biobanking

    Human Technopole – Milan, Italy

    > See All Jobs

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