 | | Vol. 16.07 – 22 February, 2024 |
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| Investigators constructed CD38 antigen receptor membrane-modified MSC-extracellular vesicles by transfecting MSCs with a lentivirus loaded with a CD38 antigen receptor–CD8 transmembrane fragment fusion plasmid to target AEC2s and alleviate pulmonary fibrosis.
[ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using single-cell transcriptomics, scientists evaluated how organoids derived from freshly isolated first-trimester trophoblasts or from established human trophoblast stem cell lines reproduce developmental cell trajectories and transcriptional regulatory processes defined in vivo.
[Developmental Cell] |
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| The authors evaluated anti-COVID antibody IgG subclass, Fc-receptor binding profile, and activity against wild-type Spike and RBD plus five variants of concern in 153 serum samples from 100 infants.
[iScience] |
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| Researchers demonstrated that the primed pluripotent state can generate trophoblast stem cells by activating pathways such as EGF and WNT, and by suppressing TGFβ, HDACs, and Rho-associated protein kinase signaling pathways, all without the addition of exogenous Bone morphogenetic protein 4.
[Scientific Reports] |
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| Investigators described the development of a human-term placenta-derived cytotrophoblast immortalized cell line (hPTCCTB) derived from the basal plate. hPTCCTB cells were comparable to their primary cells of origin in terms of morphology, marker expression, and functional responses.
[Biology Of Reproduction] |
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| A new regenerative platform based on boron enriched-acellular sheep small intestine submucosa scaffold was designed and used as a carrier for mesenchymal stem cells derived from Wharton’s jelly aiming to promote the tissue healing in burn-induced rat models.
[Biomedical Materials] |
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| Umbilical cord MSC-conditioned medium produced positive effects on a transforming growth factor beta-induced intrauterine adhesion cell model.
[Biology Open] |
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| The authors examine the effects of UC-MSCs on overall mortality as well as on organ dysfunction, coagulopathy, endothelial permeability, pathogen clearance, and systemic inflammation at prespecified time intervals in preclinical models of sepsis.
[Stem Cells Translational Medicine] |
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| Scientists summarize the establishment and maintenance of trophoblast stem cells in mammals and nontraditional animal models with a primary emphasis on epigenetic regulation of their origin while defining gaps in the current literature and areas of further development.
[Journal Of Molecular Endocrinology] |
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| Cellenkos has received approval to advance to the second cohort of patients in its clinical trial of neurotrophic T regulatory cell therapy CK0803 for ALS treatment.
[Clinical Trials Arena] |
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| three months after Health Canada issued a public health warning about the Canadian Cord Blood bioRepository facility in west Edmonton, a local couple no longer trusts that the potentially life-saving stem cells they have spent thousands of dollars to preserve remain viable or safe.
[CBC] |
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| March 21 – 23, 2024
Tokyo, Japan |
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| | University of Alberta – Edmonton, Alberta, Canada |
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| | University of Amsterdam – Amsterdam, Netherlands |
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| | University of Maryland Baltimore – Baltimore, Maryland, United States |
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| | Rutgers, New Jersey Medical School – Newark, New Jersey, United States |
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| | The University of Manchester – Manchester, England, United Kingdom |
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