Hypoxia Induces Adrenomedullin from Lung Epithelia, Stimulating ILC2 Inflammation and Immunity

Researchers reported that conditional deletion of the E3 ubiquitin ligase VHL in lung epithelial cells resulted in exacerbated type 2 responses accompanied by selective increase of group 2 innate lymphoid cells (ILC2s) at steady state and following inflammation or helminth infection.