LAMP2 Regulates Autophagy in the Thymic Epithelium and Thymic Stroma-Dependent CD4 T Cell Development

Scientists showed that lysosomal-associated membrane protein 2 (LAMP2) was highly expressed in cortical thymic epithelial cells and that genetic inactivation of Lamp2 in thymic stromal cells impaired the development of CD4 T cells that completed positive selection, without misdirecting MHC II-restricted cells into the CD8 lineage.