Human CD4⁺/CD8α⁺ Regulatory T Cells Induced by Faecalibacterium prausnitzii Protect against Intestinal Inflammation

Using a humanized model of NOD.Prkcscid IL2rγ-/- immunodeficient mouse strain that expressed the human leucocyte antigen D-related allele HLA-DR*0401 but not murine class II molecules, scientists demonstrated a protective effect of a HLA-DR*0401-restricted DP8α regulatory T cell clone combined with F. prausnitzii administration in a colitis model.