Prohaptoglobin Inhibits the Transforming Growth Factor-β-Induced Epithelial-to-Mesenchymal Transition In Vitro by Increasing Smad1/5 Activation and Suppressing the Smad2/3 Signaling Pathway in SK-Hep1 Liver Cancer Cells

By
Britya Ghosh
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Researchers demonstrated that prohaptoglobin stimulated Smad1/5 activation via ALK1, a transforming growth factor-β (TGF-β) type I receptor, in endothelial cells, suggesting that proHp played a role in TGF-β signaling.
[PLoS One]
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