Systemic Immune Dysfunction in Cancer Patients Driven by IL6 Induction of LAG3 in Peripheral CD8⁺ T Cells

Researchers demonstrated that approximately a third of cancer patients analyzed had peripheral CD8+ T cells that expressed robust intracellular lymphocyte activation gene 3 (LAG3), but not surface LAG3 due to A disintegrin and metalloproteinase domain-containing protein 10 cleavage.