STING Agonist Delivery by Tumor-Penetrating PEG-Lipid Nanodiscs Primes Robust Anticancer Immunity

Although cyclic dinucleotides (CDNs) were not directly tumoricidal, lipid nanodisc-CDN uptake by cancer cells correlated with robust T cell activation by promoting CDN and tumor antigen co-localization in dendritic cells.