The lncRNA PILA Promotes NF-κB Signaling in Osteoarthritis by Stimulating the Activity of the Protein Arginine Methyltransferase PRMT1

The authors identified PILA as a long noncoding RNA (lncRNA) that enhanced NF-κB signaling and osteoarthritis (OA). Knockdown of PILA inhibited tumor necrosis factor-induced NF-κB signaling, ECM catabolism, and apoptosis in chondrocytes, whereas ectopic expression of PILA promoted NF-κB signaling and matrix degradation.