Human CD4⁺CD25⁺CD226^– Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity versus CD4⁺CD25⁺CD127^lo/- Tregs for Adoptive Cell Therapy

Investigators suggested that the exclusion of CD226-expressing cells during Treg sorting yielded a population with increased purity, lineage stability, and suppressive capabilities, which may have benefited Treg adoptive cell therapy for the treatment of autoimmune diseases.