Accumulation of pTreg Cells Is Detrimental in Late-Onset (Aged) Mouse Model of Multiple Sclerosis

When analyzing the distribution of Treg cells in experimental autoimmune encephalomyelitis mice, the aged mice exhibited a higher proportion of polyclonal (pan-) peripheral Treg (pTreg) cells and a lower proportion of antigen-specific pTreg cells in the periphery but lower proportions of both pan- and antigen-specific Treg cells in the central nervous system.