Persistent CAD Activity in Memory CD8⁺ T Cells Supports rRNA Synthesis and Ribosomal Biogenesis Required at Rechallenge

Scientists identified a role for the initial and continued activation of the trifunctional rate-limiting enzyme of the de novo pyrimidine synthesis pathway CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) as critical in promoting the rapid recall response of previously activated CD8+ T cells.