NewslettersCell Therapy NewsTargeting PARP11 to Avert Immunosuppression and Improve CAR T Therapy in Solid TumorsBy lbeveridge - May 30, 20220243The authors found that tumor microenvironment factors, such as regulatory T cells and adenosine, downregulated type I interferon receptor IFNAR1 on CD8+ cytotoxic T lymphocytes. (CTLs).[Nature Cancer]Abstract