The Ube2m-Rbx1 Neddylation-Cullin-RING-Ligase Proteins Are Essential for the Maintenance of Regulatory T Cell Fitness

Investigators showed that mice with Treg cell-specific deletion of Rbx1, a dual E3 for both neddylation and ubiquitylation by CRLs, developed an early-onset fatal inflammatory disorder, characterized by disrupted Treg cell homeostasis and suppressive functions.