DNMT3A Mutations Define a Unique Biological and Prognostic Subgroup Associated with Cytotoxic T-cells in PTCL-NOS

Researchers investigated de novo DNA methyltransferase 3A (DNMT3A) mutations in common peripheral T-cell lymphoma (PTCL) entities, including angioimmunoblastic T cell lymphoma and novel molecular subtypes identified within PTCL-not otherwise specified designated as PTCL-GATA3 and PTCL-TBX21.