Hepatocyte-Derived MANF Mitigates Ethanol-Induced Liver Steatosis in Mice via Enhancing ASS1 Activity and Activating AMPK Pathway

Scientists reported that after chronic-plus-binge ethanol feeding, hepatocyte-specific mesencephalic astrocyte-derived neurotrophic factor (MANF) knockout mice displayed more severe hepatic steatosis and liver injury than wild-type control mice.