Human CD4⁺CD25⁺CD226^– Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity versus CD4⁺CD25⁺CD127^lo/- Tregs for Adoptive Cell Therapy

Investigators identified the autoimmune disease risk-associated locus and costimulatory molecule, CD226, as being highly expressed not only on effector T cells but also, interferon-γ producing peripheral Tregs.