Ex Vivo-Expanded Human CD19⁺TIM-1⁺ Regulatory B Cells Suppress Immune Responses In Vivo and Are Dependent upon the TIM-1/STAT3 Axis

Scientists reported ex vivo expansion of human B cells with in vivo regulatory function. CD154-stimulation of human CD19+ B cells drove >900-fold expansion of IL-10+ B cells that was maintained in culture for 14 days.