Application of Blood Brain Barrier Models in Pre-Clinical Assessment of Glioblastoma-Targeting CAR-T Based Immunotherapies

Researchers used induced pluripotent stem cells-derived brain endothelial-like cell transwell co-culture model to assess blood brain barrier extravasation of CAR-T based immunotherapies targeting U87MG human glioblastoma cells overexpressing the tumor-specific mutated protein EGFRvIII.