Mitochondrial Reactive Oxygen Is Critical for IL-12/IL-18-Induced IFN-γ Production by CD4⁺ T Cells and Is Regulated by Fas/FasL Signaling

Investigators found that mitochondrial reactive oxygen species were required for IL-12 plus IL-18-driven production of IFN-γ, an essential cytokine for inflammatory and autoimmune disease development.