Re-Programming Mouse Liver-Resident Invariant Natural Killer T Cells for Suppressing Hepatic and Diabetogenic Autoimmunity

The authors showed that mouse and human liver-resident αGalCer/CD1d-binding invariant natural killer T cells largely corresponded to a novel Zbtb16+Tbx21+Gata3+MaflowRorc– subset that exhibited profound transcriptional, phenotypic, and functional plasticity.