Upregulation of NKG2D Ligands Impairs Hematopoietic Stem Cell Function in Fanconi Anemia

Researchers demonstrated the involvement of NKG2D/Natural Killer group 2 member D ligands (NKG2D-L) interactions in Fanconi Anemia (FA) HSPC functionality, suggesting an unexpected role of the immune system in the progressive bone marrow failure characteristic of FA.