Extramedullary Hematopoiesis: Mesenchymal Stromal Cells From Spleen Provide an In Vitro niche for myelopoiesis

The authors showed that splenic stroma of both human and murine origin provided a mesenchymal stromal cell microenvironment which was WNT pathway–dependent, and supported in vitro myelopoiesis with production of specific subsets of myeloid and dendritic-like cells.