GDAP1 Loss of Function Inhibits the Mitochondrial Pyruvate Dehydrogenase Complex by Altering the Actin Cytoskeleton

Scientists reported that patient-derived motoneurons and ganglioside-induced differentiation-associated protein 1 (GDAP1) knockdown SH-SY5Y cells display two phenotypes: more tubular mitochondria and a metabolism characterized by glutamine dependence and fewer cytosolic lipid droplets.