Image Analysis Reveals Molecularly Distinct Patterns of TILs in NSCLC Associated With Treatment Outcome

The study of over 1000 lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumors demonstrated that computationally derived patterns of tumor-infiltrating lymphocytes (TILs) on H&E images were different between LUAD (N = 421) and LUSC (N = 438), with TIL density being prognostic of overall survival in LUAD and spatial arrangement being more prognostically relevant in LUSC.