Recapitulated Crosstalk Between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip

A novel 3D microfluidic tri-culture platform was proposed for recapitulating positive feedback from brain metastatic NSCLC and astrocytes and brain-specific endothelial cells, two major players in brain tumor microenvironment.