Syntaxin 18 Regulates the DNA Damage Response and Epithelial-to-Mesenchymal Transition To Promote Radiation Resistance of Lung Cancer

In an unbiased functional genetic screen for radiosensitization targets in lung cancer, scientists identified syntaxin 18, a protein involved in retrograde vesicular transport between the Golgi apparatus and endoplasmic reticulum, as mediator of radioresistance.