Memory-Like NK Cells Armed with a Neoepitope-Specific CAR Exhibit Potent Activity against NPM1 Mutated Acute Myeloid Leukemia

Researchers showed that arming cytokine-induced memory-like NK cells with a neoepitope-specific CAR significantly enhanced their antitumor responses to nucleophosphmin-1 (NPM1)-mutated acute myeloid leukemia while avoiding off-target toxicity.