Targeting LSD1 Rescues MHC Class I Antigen Presentation and Overcomes PD-L1 Blockade Resistance in Small Cell Lung Cancer

Scientists demonstrated that targeted inhibition of lysine-specific demethylase 1 (LSD1) in small cell lung cancer restored major histocompatibility complex (MHC) class I cell surface expression and transcriptionally activated genes encoding the antigen presentation pathway.